A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
http://www.nature.com/articles/ng0195-70.pdf
Reference19 articles.
1. Knudson, A.G. Antloncogenes and human cancer. Proc. natn. Acad. Sci. U.S.A 90, 10914–10921 (1993).
2. Eker, R. & Mosslge, J.A. A dominant gene for renal adenomas in the rats. Nature 189, 858–859 (1961).
3. Everitt, J.I., Goldsworthy, T.L., Wolf, D.C. & Walker, C.L. Hereditary renal cell carcinoma In the Eker rat: a rodent familial cancer syndrome. J. Urol. 148, 1932–1936 (1992).
4. Hino, O. et al. Spontaneous and radiation-induced renal tumours in the Eker rat model of dominantly inherited cancer. Proc. natl. Acad. Sci. U.S.A. 90, 327–331 (1993).
5. Yeung, R.S., Buetow, K.H., Testa, J.R. & Knudson, A.Q. Susceptibility to renal carcinoma In the Eker rat Involves a tumour suppressor gene on chromosome 10. Proc. natl. Acad. Sci. U.S.A 90, 8038–8042 (1993).
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