Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/ncomms15695.pdf
Reference63 articles.
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3. Khersonsky, O. & Tawfik, D. S. Enzyme promiscuity: a mechanistic and evolutionary perspective. Annu. Rev. Biochem. 79, 471–505 (2010).
4. Bloom, J. D. & Arnold, F. H. In the light of directed evolution: pathways of adaptive protein evolution. Proc. Natl Acad. Sci. USA. 106, (Suppl) 9995–10000 (2009).
5. Orr, H. A. The genetic theory of adaptation: a brief history. Nat. Rev. Genet. 6, 119–127 (2005).
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