Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/ncomms15095.pdf
Reference37 articles.
1. Vonderheide, R. H. & Bayne, L. J. Inflammatory networks and immune surveillance of pancreatic carcinoma. Curr. Opin. Immunol. 25, 200–205 (2013).
2. Schmitz-Winnenthal, F. H. et al. High frequencies of functional tumour-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res. 65, 10079–10087 (2005).
3. Shibuya, K. C. et al. Pancreatic ductal adenocarcinoma contains an effector and regulatory immune cell infiltrate that is altered by multimodal neoadjuvant treatment. PLoS ONE 9, e96565 (2014).
4. Fukunaga, A. et al. CD8+ tumour-infiltrating lymphocytes together with CD4+ tumour-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma. Pancreas 28, e26-31 (2004).
5. Ene-Obong, A. et al. Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology 145, 1121–1132 (2013).
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