Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/ncomms15334.pdf
Reference54 articles.
1. Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819–823 (2013).
2. Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
3. Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823–826 (2013).
4. Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822–826 (2013).
5. Hsu, P. D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 31, 827–832 (2013).
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