A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action-Reference-Cited by-同舟云学术

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Published:2017-06-09 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Campaner Elena,Rustighi Alessandra,Zannini Alessandro,Cristiani Alberto,Piazza Silvano^ORCID,Ciani Yari,Kalid Ori,Golan Gali,Baloglu Erkan,Shacham Sharon,Valsasina Barbara,Cucchi Ulisse,Pippione Agnese Chiara,Lolli Marco Lucio,Giabbai Barbara,Storici Paola^ORCID,Carloni Paolo,Rossetti Giulia,Benvenuti Federica,Bello Ezia,D’Incalci Maurizio,Cappuzzello Elisa^ORCID,Rosato Antonio,Del Sal Giannino

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms15772.pdf

Reference58 articles.

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2. Liou, Y. C., Zhou, X. Z. & Lu, K. P. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem. Sci. 36, 501–514 (2011).

3. Hanes, S. D. Prolyl isomerases in gene transcription. Biochim. Biophys. Acta–Gener. Subj. 1850, 2017–2034 (2015).

4. Lu, Z. & Hunter, T. Prolyl isomerase Pin1 in cancer. Cell Res. 24, 1033–1049 (2014).

5. Zhou, X. Z. & Lu, K. P. The isomerase Pin1 controls numerous cancer-driving pathways acting as a unique drug target. Nat. Rev. Cancer 16, 463–478 (2016).

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