Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase-Reference-Cited by-同舟云学术

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Published:2017-06-12 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Hutchinson Jonathan P.,Rowland Paul,Taylor Mark R. D.,Christodoulou Erica M.,Haslam Carl,Hobbs Clare I.,Holmes Duncan S.,Homes Paul,Liddle John,Mole Damian J.^ORCID,Uings Iain,Walker Ann L.,Webster Scott P.,Mowat Christopher G.,Chung Chun-wa

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms15827.pdf

Reference45 articles.

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3. Zwilling, D. et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell 145, 863–874 (2011).

4. Giorgini, F., Guidetti, P., Nguyen, Q., Bennett, S. C. & Muchowski, P. J. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat. Genet. 37, 526–531 (2005).

5. Lovelace, M. D. et al. Current evidence for a role of the kynurenine pathway of tryptophan metabolism in multiple sclerosis. Front. Immunol. 7, 246 (2016).

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