An orally delivered small-molecule formulation with antiangiogenic and anticancer activity

Author:

Benny Ofra,Fainaru Ofer,Adini Avner,Cassiola Flavia,Bazinet Lauren,Adini Irit,Pravda Elke,Nahmias Yaakov,Koirala Samir,Corfas Gabriel,D'Amato Robert J,Folkman Judah

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference42 articles.

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3. Ingber, D. et al. Synthetic analogue of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348, 555–557 (1990).

4. Folkman, J. & Kalluri, R. Tumor angiogenesis. in Cancer Medicine Vol. 1. (ed. Kufe, D. et al.) 161–194 (B.C. Decker Inc., Hamilton, Ontario, 2003).

5. Yamaoka, M., Yamamoto, T., Ikeyama, S., Sudo, K. & Fujita, T. Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Cancer Res. 53, 5233–5236 (1993).

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