Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss-Reference-Cited by-同舟云学术

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Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

Published:2019-06-07 Issue:10 Volume:32 Page:1434-1446
ISSN:0893-3952
Container-title:Modern Pathology
language:en
Short-container-title:Mod Pathol

Author:

Marchione Dylan M.^ORCID,Lisby Amanda,Viaene Angela N.,Santi Mariarita,Nasrallah MacLean,Wang Li-Ping,Williams Erik A.,Larque Ana B.,Chebib Ivan,Garcia Benjamin A.,Wojcik John B.

Funder

U.S. Department of Health & Human Services | National Institutes of Health

Leukemia and Lymphoma Society Robert Arceci Scholar Award

University of Pennsylvania Perelman School of Medicine Department of Pathology and Laboratory Medicine Institutional Startup Funds

Publisher

Springer Science and Business Media LLC

Subject

Pathology and Forensic Medicine

Link

http://www.nature.com/articles/s41379-019-0287-8.pdf

Reference49 articles.

1. Rodriguez FJ, Folpe AL, Giannini C, Perry A. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol. 2012;123:295–319.

2. Hornick JL Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics. Mod Pathol. 2019. https://doi.org/10.1038/s41379-018-0139-y .

3. Zou C, Smith KD, Liu J, Lahat G, Myers S, Wang WL, et al. Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg. 2009;249:1014–22.

4. Le Guellec S, Decouvelaere A-V, Filleron T, Valo I, Charon-Barra C, Robin YM, et al. Malignant peripheral nerve sheath tumor is a challenging diagnosis: a systematic pathology review, immunohistochemistry, and molecular analysis in 160 patients from the french sarcoma group database. Am J Surg Pathol. 2016;40:896–908.

5. Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada CN, Lin M, et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet. 2014;46:1227–32.

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