A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation

Author:

Le Loarer François,Cleven Arjen H. G.,Bouvier Corinne,Castex Marie-Pierre,Romagosa Cleofe,Moreau Anne,Salas Sébastien,Bonhomme Benjamin,Gomez-Brouchet Anne,Laurent Camille,Le Guellec Sophie,Audard Virginie,Giraud Antoine,Ramos-Oliver IrmaORCID,Cleton-Jansen Anne-Marie,Savci-Heijink Dilara C.,Kroon Herman M.,Baud Jessica,Pissaloux Daniel,Pierron Gaëlle,Sherwood AnandORCID,Coindre Jean Michel,Bovée Judith V. M. G.,Larousserie Frédérique,Tirode FranckORCID

Publisher

Springer Science and Business Media LLC

Subject

Pathology and Forensic Medicine

Reference34 articles.

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2. Mosquera JM, Sboner A, Zhang L, Kitabayashi N, Chen CL, Sung YS, et al. Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. Genes Chromosomes Cancer. 2013;52:538–50.

3. Alaggio R, Zhang L, Sung YS, Huang SC, Chen CL, Bisogno G, et al. A molecular study of pediatric spindle and sclerosing rhabdomyosarcoma: identification of novel and recurrent VGLL2-related fusions in infantile cases. Am J Surg Pathol. 2016;40:224–35.

4. Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, et al. A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Nat Genet. 2014;46:595–600.

5. Szuhai K, de Jong D, Leung WY, Fletcher CD, Hogendoorn PC. Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. J Pathol. 2014;232:300–7.

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