Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections

Author:

Mukhopadhyay SanjayORCID,Dermawan Josephine K.,Lanigan Christopher P.,Farver Carol F.

Funder

Departmental funding

Publisher

Springer Science and Business Media LLC

Subject

Pathology and Forensic Medicine

Reference25 articles.

1. Goto Y, de Silva MG, Toscani A, et al. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with “zinc-finger” DNA-binding motifs. J Biol Chem. 1992;267:15252–7.

2. Lan MS, Russell EK, Lu J, et al. IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines. Cancer Res. 1993;53:4129–440.

3. Xie J, Cai T, Zhang H, et al. The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. Genomics. 2002;80:54–61.

4. Lan MS, Li Q, Modi WS, et al. Genomic organization, 5́ upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. J Biol Chem. 1994;269:14170–4.

5. Breslin MB, Zhu M, Notkins AL, et al. Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. Nucleic Acids Res. 2002;30:1038–45.

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