Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system-Reference-Cited by-同舟云学术

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Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system

Published:2016-03 Issue:3 Volume:7 Page:e2124-e2124
ISSN:2041-4889
Container-title:Cell Death & Disease
language:en
Short-container-title:Cell Death Dis

Author:

Wang K,Xu R,Snider A J,Schrandt J,Li Y,Bialkowska A B,Li M,Zhou J,Hannun Y A,Obeid L M,Yang V W,Mao C

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/cddis201636.pdf

Reference58 articles.

1. Mullen TD, Hannun YA, Obeid LM . Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J 2012; 441: 789–802.

2. Mao C, Obeid LM . Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta 2008; 1781: 424–434.

3. Sakata A, Ochiai T, Shimeno H, Hikishima S, Yokomatsu T, Shibuya S et al. Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice. Immunology 2007; 122: 54–64.

4. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG et al. Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res 2010; 51: 2785–2797.

5. Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K et al. Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem 2013; 288: 2923–2932.

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