Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak-Reference-Cited by-同舟云学术

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Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak

Published:2012-08 Issue:8 Volume:3 Page:e372-e372
ISSN:2041-4889
Container-title:Cell Death & Disease
language:en
Short-container-title:Cell Death Dis

Author:

Melarangi T,Zhuang J,Lin K,Rockliffe N,Bosanquet A G,Oates M,Slupsky J R,Pettitt A R

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/cddis2012102.pdf

Reference41 articles.

1. Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S . From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010; 10: 37–50.

2. Thornton PD, Matutes E, Bosanquet AG, Lakhani AK, Grech H, Ropner JE et al. High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities. Ann Hematol 2003; 82: 759–765.

3. Castro JE, Sandoval-Sus JD, Bole J, Rassenti L, Kipps TJ . Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia. Leukemia 2008; 22: 2048–2053.

4. Dungarwalla M, Evans SO, Riley U, Catovsky D, Dearden CE, Matutes E . High dose methylprednisolone and rituximab is an effective therapy in advanced refractory chronic lymphocytic leukemia resistant to fludarabine therapy. Haematologica 2008; 93: 475–476.

5. Castro JE, James DF, Sandoval-Sus JD, Jain S, Bole J, Rassenti L et al. Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. Leukemia 2009; 23: 1779–1789.

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1. The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation;Journal of Biological Chemistry;2024-08

2. Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2020-12

3. Molecular mechanisms contributing to glucocorticoid resistance in lymphoid malignancies;Cancer Drug Resistance;2019

4. Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies;Journal of Proteomics;2018-05

5. Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome;Scientific Reports;2017-12

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