MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway-Reference-Cited by-同舟云学术

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MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway

Published:2017-05 Issue:5 Volume:8 Page:e2776-e2776
ISSN:2041-4889
Container-title:Cell Death & Disease
language:en
Short-container-title:Cell Death Dis

Author:

Xiang Ru-Fang,Wang Yan,Zhang Nan,Xu Wen-Bin,Cao Yang,Tong Jia,Li Jun-min,Wu Ying-Li,Yan Hua

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/cddis2017188.pdf

Reference36 articles.

1. Siegel RL, Miller KD, Jemal A . Cancer statistics. CA Cancer J Clin 2016; 66: 7–30.

2. Rossi M, Di Martino MT, Morelli E, Leotta M, Rizzo A, Grimaldi A et al. Molecular targets for the treatment of multiple myeloma. Curr Cancer Drug Targets 2012; 12: 757–767.

3. Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, González-Barón M . PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 2004; 30: 193–204.

4. Hsu J, Shi Y, Krajewski S, Renner S, Fisher M, Reed JC et al. The AKT kinase is activated in multiple myeloma tumor cells. Blood 2001; 98: 2853–2855.

5. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M et al. Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem 2013; 288: 30399–30410.

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