Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.4284.pdf
Reference36 articles.
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2. Chen-Izu, Y. et al. Na+ channel function, regulation, structure, trafficking and sequestration. J. Physiol. (Lond.) 593, 1347–1360 (2015).
3. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N. Engl. J. Med. 321, 406–412 (1989).
4. Marionneau, C. & Abriel, H. Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications. J. Mol. Cell. Cardiol. 82, 36–47 (2015).
5. Pei, Z., Xiao, Y., Meng, J., Hudmon, A. & Cummins, T.R. Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation. Nat. Commun. 7, 12035 (2016).
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