Abstract
AbstractMany overweight or obese people struggle to sustain the behavioural changes necessary to achieve and maintain weight loss. In rodents, obesogenic diet can disrupt goal-directed control of responding for food reinforcers, which may indicate that diet can disrupt brain regions associated with behavioural control. We investigated a potential glutamatergic mechanism to return goal-directed control to rats who had been given an obesogenic diet prior to operant training. We found that an obesogenic diet reduced goal-directed control and that systemic injection of LY379268, a Group II metabotropic glutamate receptor (mGluR2/3) agonist, returned goal-directed responding in these rats. Further, we found that direct infusion of LY379268 into the dorsomedial striatum, a region associated with goal-directed control, also restored goal-directed responding in the obesogenic-diet group. This indicates that one mechanism through which obesogenic diet disrupts goal-directed control is glutamatergic, and infusion of a mGluR2/3 agonist into the DMS is sufficient to ameliorate deficits in goal-directed control.
Funder
Gouvernement du Canada | Canadian Institutes of Health Research
Publisher
Springer Science and Business Media LLC
Subject
Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health
Reference68 articles.
1. Overweight and Obesity. 2020. World Health Organization. Retrieved October 27, 2020, from https://www-who-int.myaccess.library.utoronto.ca/news-room/fact-sheets/detail/obesity-and-overweight (2020).
2. Montesi L, Ghoch M, el, Brodosi L, Calugi S, Marchesini G, Grave RD. Long-term weight loss maintenance for obesity: A multidisciplinary approach. Diabetes, Metab Syndr Obes: Targets Ther 2016;9:37–46.
3. Cleo G, Glasziou P, Beller E, Isenring E, Thomas R. Habit-based interventions for weight loss maintenance in adults with overweight and obesity: a randomized controlled trial. Int J Obes. 2019;43:374–83.
4. Furlong TM, Jayaweera HK, Balleine BW, Corbit LH. Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum. J Neurosci. 2014;34:5012–22.
5. Kendig MD, Cheung AMK, Raymond JS, Corbit LH Contexts paired with junk food impair goal-directed behavior in rats: Implications for decision making in obesogenic environments. Frontiers in Behavioral Neuroscience 2016;10. https://doi.org/10.3389/fnbeh.2016.00216.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献