Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans

Author:

Bourassa Kyle J.ORCID,Garrett Melanie E.,Caspi AvshalomORCID,Dennis Michelle,Hall Katherine S.,Moffitt Terrie E.,Taylor Gregory A., ,Beckham Jean C.,Calhoun Patrick S.,Dedert Eric,Elbogen Eric B.,Hurley Robin A.,Kilts Jason D.,Kimbrel Nathan A.,Kirby Angela,Martindale Sarah L.,Marx Christine E.,McDonald Scott D.,Moore Scott D.,Morey Rajendra A.,Naylor Jennifer C.,Rowland Jared A.,Shura Robert,Swinkels Cindy,Van Voorhees Elizabeth E.,Wagner H. Ryan,Magnante Anna T.,O’Connor Victoria L.,Aurora Pallavi,Martinez Brandy S.,Halverson Tate F.,Ashley-Koch Allison E.ORCID,Beckham Jean C.ORCID,Kimbrel Nathan A.ORCID

Abstract

AbstractPeople who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chronic diseases, disability, and premature mortality. Using data from 2309 post-9/11 United States military veterans who participated in the VISN 6 MIRECC’s Post-Deployment Mental Health Study, we tested whether PTSD and trauma exposure were associated with accelerated rate of biological aging, assessed using a validated DNA methylation (DNAm) measure of epigenetic aging—DunedinPACE. Veterans with current PTSD were aging faster than those who did not have current PTSD, β = 0.18, 95% CI [0.11, 0.27], p < .001. This effect represented an additional 0.4 months of biological aging each year. Veterans were also aging faster if they reported more PTSD symptoms, β = 0.13, 95% CI [0.09, 0.16], p < 0.001, or higher levels of trauma exposure, β = 0.09, 95% CI [0.05, 0.13], p < 0.001. Notably, veterans with past PTSD were aging more slowly than those with current PTSD, β = -0.21, 95% CI [-0.35, -0.07], p = .003. All reported results accounted for age, gender, self-reported race/ethnicity, and education, and remained when controlling for smoking. Our findings suggest that an accelerated rate of biological aging could help explain how PTSD contributes to poor health and highlights the potential benefits of providing efficacious treatment to populations at increased risk of trauma and PTSD.

Funder

Office of Research and Development

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Biomedical Laboratory Research and Development, VA Office of Research and Development

Publisher

Springer Science and Business Media LLC

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory;Translational Psychiatry;2024-07-12

2. Demographic characteristics and epigenetic biological aging among post-9/11 veterans: Associations of DunedinPACE with sex, race, and age;Psychiatry Research;2024-06

3. SLEEP QUALITY AND AVOIDANCE BEHAVIOR IN COMBATANTS WITH POST-TRAUMATIC STRESS DISORDER;Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії;2024-05-20

4. BIOLOGICAL AND PSYCHOLOGICAL ASPECTS OF AGING IN YOUNG WOMEN IN THE CONDITIONS OF MILITARY AGGRESSION;World of Medicine and Biology;2024

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