Abstract
AbstractWe simultaneously revisited the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) with a comprehensive data-analytics strategy. Here, the combination of pattern-analysis algorithms and extensive data resources (n = 266 patients aged 7–49 years) allowed identifying coherent clinical constellations in and across ADI-R and ADOS assessments widespread in clinical practice. Our clustering approach revealed low- and high-severity patient groups, as well as a group scoring high only in the ADI-R domains, providing quantitative contours for the widely assumed autism subtypes. Sparse regression approaches uncovered the most clinically predictive questionnaire domains. The social and communication domains of the ADI-R showed convincing performance to predict the patients’ symptom severity. Finally, we explored the relative importance of each of the ADI-R and ADOS domains conditioning on age, sex, and fluid IQ in our sample. The collective results suggest that (i) identifying autism subtypes and severity for a given individual may be most manifested in the ADI-R social and communication domains, (ii) the ADI-R might be a more appropriate tool to accurately capture symptom severity, and (iii) the ADOS domains were more relevant than the ADI-R domains to capture sex differences.
Publisher
Springer Science and Business Media LLC
Subject
Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health
Reference46 articles.
1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. BMC Med. 17, 133–137 (2013).
2. Kamp-Becker, I. et al. Categorical and dimensional structure of autism spectrum disorders: the nosologic validity of Asperger syndrome. J. Autism Dev. Disord. 40, 921–929 (2010).
3. Lord, C. et al. A multisite study of the clinical diagnosis of different autism spectrum disorders. Arch. Gen. Psychiatry 69, 306–313 (2012).
4. Frith, U. & Happé, F. Autism spectrum disorder. Curr. Biol. 15, R786–R790 (2005).
5. Mottron, L. & Bzdok, D. Autism spectrum heterogeneity: fact or artifact? Mol. Psychiatry 1–8 (2020).
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献