Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease-Reference-Cited by-同舟云学术

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

Published:2019-01-31 Issue:1 Volume:9 Page:
ISSN:2158-3188
Container-title:Translational Psychiatry
language:en
Short-container-title:Transl Psychiatry

Author:

Dalmasso Maria Carolina,Brusco Luis Ignacio,Olivar Natividad,Muchnik Carolina,Hanses Claudia,Milz Esther,Becker Julian,Heilmann-Heimbach Stefanie,Hoffmann Per^ORCID,Prestia Federico A.,Galeano Pablo^ORCID,Avalos Mariana Soledad Sanchez,Martinez Luis Eduardo,Carulla Mariana Estela,Azurmendi Pablo Javier^ORCID,Liberczuk Cynthia,Fezza Cristina,Sampaño Marcelo,Fierens Maria,Jemar Guillermo,Solis Patricia,Medel Nancy,Lisso Julieta,Sevillano Zulma,Bosco Paolo,Bossù Paola,Spalletta Gianfranco,Galimberti Daniela,Mancuso Michelangelo,Nacmias Benedetta,Sorbi Sandro,Mecocci Patrizia,Pilotto Alberto,Caffarra Paolo,Panza Francesco^ORCID,Bullido Maria,Clarimon Jordi,Sánchez-Juan Pascual,Coto Eliecer,Sanchez-Garcia Florentino,Graff Caroline,Ingelsson Martin,Bellenguez Céline^ORCID,Castaño Eduardo Miguel,Kairiyama Claudia,Politis Daniel Gustavo,Kochen Silvia,Scaro Horacio,Maier Wolfgang,Jessen Frank,Mangone Carlos Alberto,Lambert Jean-Charles^ORCID,Morelli Laura,Ramirez Alfredo^ORCID

Funder

Bundesministerium für Bildung und Forschung

Alexander von Humboldt-Stiftung

Ministry of Science, Technology and Productive Innovation, Argentina | Agencia Nacional de Promoción Científica y Tecnológica

Ministry of Science, Technology and Productive Innovation, Argentina | National Agency for Science and Technology, Argentina | Fondo para la Investigación Científica y Tecnológica

Publisher

Springer Science and Business Media LLC

Subject

Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health

Link

http://www.nature.com/articles/s41398-019-0394-9.pdf

Reference23 articles.

1. Gatz, M. et al. Role of genes and environments for explaining Alzheimer Disease. Arch. Gen. Psychiatry 63, 168 (2006).

2. Naj, A. C. & Schellenberg, G. D. Genomic variants, genes, and pathways of Alzheimer’s disease: an overview. Am. J. Med Genet. B Neuropsychiatr. Genet. 174, 5–26 (2017).

3. Del-Aguila, J. L. et al. Alzheimer’s disease: rare variants with large effect sizes. Curr. Opin. Genet. Dev. 33, 49–55 (2015).

4. Sims, R. et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. Nat. Genet. 49, 1373–1384 (2017).

5. Benitez, Ba et al. TREM2 is associated with the risk of Alzheimer’s disease in Spanish population. Neurobiol. Aging 34, 1711.e15–7 (2013).

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes;PLOS ONE;2024-03-29

2. A guide to selecting high-performing antibodies for PLC-gamma-2 for use in Western Blot, immunoprecipitation and immunofluorescence;F1000Research;2024-01-18

3. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease;Molecular Neurodegeneration;2023-11-29

4. The first genome‐wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease;Alzheimer's & Dementia;2023-11-20

5. The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition;2023-09-08