Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise
Author:
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Link
https://www.nature.com/articles/s41574-020-0405-1.pdf
Reference186 articles.
1. Battaglia, G. M., Zheng, D., Hickner, R. C. & Houmard, J. A. Effect of exercise training on metabolic flexibility in response to a high-fat diet in obese individuals. Am. J. Physiol. Endocrinol. Metab. 303, E1440–E1445 (2012). This study shows that individuals with obesity are inflexible in adapting lipid metabolism to a high-fat diet, but exercise training can induce lipid metabolic improvements in individuals with obesity.
2. Lundsgaard, A. M. et al. Mechanisms preserving insulin action during high dietary fat intake. Cell Metab. 29, 229 (2019). A paper showing that 6 weeks of a eucaloric high-fat diet in young men preserves insulin sensitivity and induces lipid metabolic adaptations.
3. Chokkalingam, K. et al. High-fat/low-carbohydrate diet reduces insulin-stimulated carbohydrate oxidation but stimulates nonoxidative glucose disposal in humans: an important role for skeletal muscle pyruvate dehydrogenase kinase 4. J. Clin. Endocrinol. Metab. 92, 284–292 (2007).
4. Thomas, C. D. et al. Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am. J. Clin. Nutr. 55, 934–942 (1992). Research demonstrating that high-fat diet intake increases fatty acid oxidation in lean individuals but not in individuals with obesity.
5. Blaak, E. E. et al. Fat oxidation before and after a high fat load in the obese insulin-resistant state. J. Clin. Endocrinol. Metab. 91, 1462–1469 (2006).
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