Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Link
https://www.nature.com/articles/s41574-023-00826-3.pdf
Reference121 articles.
1. Carre, A. & Mallone, R. Making insulin and staying out of autoimmune trouble: the beta-cell conundrum. Front. Immunol. 12, 639682 (2021).
2. Anderson, A. M. et al. Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proc. Natl Acad. Sci. USA 118, e2107208118 (2021).
3. Gonzalez-Duque, S. et al. Conventional and neo-antigenic peptides presented by β cells are targeted by circulating naive CD8+ T cells in type 1 diabetic and healthy donors. Cell Metab. 28, 946–960.e6 (2018).
4. Azoury, M. E. et al. Peptides derived from insulin granule proteins are targeted by CD8+ T cells across MHC class I restrictions in humans and NOD mice. Diabetes 69, 2678–2690 (2020).
5. Damond, N. et al. A map of human type 1 diabetes progression by imaging mass cytometry. Cell Metab. 29, 755–768.e5 (2019).
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