Abstract
AbstractPersistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4+ and CD8+ T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections.
Publisher
Springer Science and Business Media LLC
Reference44 articles.
1. Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727–733 (2020).
2. Lu, R. et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 395, 565–574 (2020).
3. World-Health-Organization. Weekly epidemiological update on COVID-19 - 25 January 2023 https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19 (Accessed on 25th January 2023).
4. Gao, Z. et al. A systematic review of asymptomatic infections with COVID-19. J. Microbiol. Immunol. Infect. 54, 12–16 (2021).
5. Chen, Z., Wang, B., Mao, S. & Ye, Q. Assessment of global asymptomatic SARS-CoV-2 infection and management practices from China. Int J. Biol. Sci. 17, 1119–1124 (2021).