Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia-Reference-Cited by-同舟云学术

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Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Published:2019-11-01 Issue:1 Volume:4 Page:
ISSN:2059-3635
Container-title:Signal Transduction and Targeted Therapy
language:en
Short-container-title:Sig Transduct Target Ther

Author:

Wang Tingting,Shatara Margaret,Liu Fangbing,Knight Tristan,Edwards Holly,Wang Guan,Lin Hai,Wang Yue,Taub Jeffrey W.,Ge Yubin

Funder

National Natural Science Foundation of China

Children's Hospital of Michigan Foundation

Hyundai Motor Group | Hyundai Motor America | Hyundai Hope On Wheels

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics

Link

http://www.nature.com/articles/s41392-019-0076-3.pdf

Reference8 articles.

1. Drygin, D., Rice, W. G. & Grummt, I. The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu. Rev. Pharmacol. Toxicol. 50, 131–156 (2010).

2. Hein, N. et al. Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population. Blood 129, 2882–2895 (2017).

3. Negi, S. S. & Brown, P. Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells. Oncotarget 6, 34846–34858 (2015).

4. Negi, S. S. & Brown, P. rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. Oncotarget 6, 18094–18104 (2015).

5. Drygin, D. et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res. 71, 1418–1430 (2011).

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3. Molecular Dynamics Study on the Binding of an Anticancer DNA G-Quadruplex Stabilizer, CX-5461, to Human Telomeric, c-KIT1, and c-Myc G-Quadruplexes and a DNA Duplex;Journal of Chemical Information and Modeling;2020-08-21

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