PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
http://www.nature.com/articles/s41392-019-0053-x.pdf
Reference5 articles.
1. Yao, H. et al. Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours. Nat. Biomed. Eng. 3, 306–317 (2019).
2. Friedman, C. F. & Snyder, A. Atypical autoimmune adverse effects with checkpoint blockade therapies. Ann. Oncol. 28, 206–207 (2017).
3. Escors, D. et al. The intracellular signalosome of PD-L1 in cancer cells. Signal Transduct Target Ther. 3, 26 (2018).
4. Wang, Y. et al. Regulation of PD-L1: emerging routes for targeting tumor immune evasion. Front Pharmacol. 9, 536 (2018).
5. Runkle, K. B. et al. Inhibition of DHHC20-mediated EGFR palmitoylation creates a dependence on EGFR signaling. Mol. Cell 62, 385–396 (2016).
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