YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor activity of ABT-199 in diffuse large B cell lymphoma
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
http://www.nature.com/articles/s41392-020-00236-1.pdf
Reference5 articles.
1. Karube, K. & Campo, E. MYC alterations in diffuse large B-cell lymphomas. Semin Hematol.52, 97–106 (2015).
2. Ott, G., Rosenwald, A. & Campo, E. Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification. Blood122, 3884–3891 (2013).
3. Esteve-Arenys, A. et al. The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma. Oncogene37, 1830–1844 (2018).
4. Chen, G.-Q., Xu, Y., Shen, S.-M. & Zhang, J. Phenotype and target-based chemical biology investigations in cancers. Natl Sci. Rev.6, 1111–1127 (2019).
5. Wang, Y. et al. YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells. Cell Death Discov.4, 44 (2018).
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