Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection
Author:
Funder
Department of Biotechnology, Ministry of Science and Technology
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
http://www.nature.com/articles/s41392-021-00470-1.pdf
Reference5 articles.
1. Clausen, T. M. et al. SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2. Cell 183, 1–15 (2020).
2. Lan, J. et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 581, 215–220 (2020).
3. Kim, S. Y. et al. Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions. Antiviral Res. 181, 104873 (2020).
4. Lang, J. et al. Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans. PLoS ONE 6, e23710 (2011).
5. Kwon, P. S. et al. Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro. Cell Discov. 6, 50 (2020).
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