Cis-regulatory decoy disrupts autorepression: a potential escape-resistant anti-viral therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
https://www.nature.com/articles/s41392-022-01187-5.pdf
Reference4 articles.
1. Chaturvedi, S. et al. Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents. Cell 185, 2086–2102.e2022 (2022).
2. Morishita, R. et al. A gene-therapy strategy using a transcription factor decoy of the E2f binding-site inhibits smooth-muscle proliferation in-vivo. Proc. Natl Acad. Sci. USA 92, 5855–5859 (1995).
3. Hecker, M. & Wagner, A. H. Transcription factor decoy technology: a therapeutic update. Biochem. Pharm. 144, 29–34 (2017).
4. Mulamba, G. B. et al. Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922). Antimicrob. Agents Chemother. 42, 971–973 (1998).
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