The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
https://www.nature.com/articles/s41392-023-01386-8.pdf
Reference10 articles.
1. Spudich, S. & Nath, A. Nervous system consequences of COVID-19. Science (New York, NY) 375, 267–269 (2022).
2. Fernández-Castañeda, A. et al. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 185, 2452–2468.e2416 (2022).
3. Zhang, B. et al. SARS-CoV-2 infects human neural progenitor cells and brain organoids. Cell Res. 30, 928–931 (2020).
4. Tziortzouda, P., Van Den Bosch, L. & Hirth, F. Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation. Nat. Rev. Neurosci. 22, 197–208 (2021).
5. Zhang, Y. et al. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc. Natl. Acad. Sci. USA 106, 7607–7612 (2009).
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