A novel model of molnupiravir against SARS-CoV-2 replication: accumulated RNA mutations to induce error catastrophe
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
https://www.nature.com/articles/s41392-021-00837-4.pdf
Reference5 articles.
1. Kabinger, F. et al. Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat. Struct. Mol. Biol. 28, 740–746 (2021).
2. Wahl, A. et al. SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801. Nature 591, 451–457 (2021).
3. Robson, F. et al. Coronavirus RNA proofreading: molecular basis and therapeutic targeting. Mol. Cell. 79, 710–727 (2020).
4. Kokic, G. et al. Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat. Commun. 12, 279 (2021).
5. Zhou, S. et al. β-d-N4-hydroxycytidine (NHC) inhibits SARS-CoV-2 through lethal mutagenesis but is also mutagenic to mammalian cells. J. Infect. Dis. 224, 415–419 (2021).
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