“Clone-specific” antibody-drug conjugates: an innovative strategy in the treatment of T-cell cancers
Author:
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41392-024-01945-7.pdf
Reference5 articles.
1. Nichakawade, T. D. et al. TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers. Nature 628, 416–423 (2024).
2. Younes, A., Yasothan, U. & Kirkpatrick, P. Brentuximab vedotin. Nat. Rev. Drug Discov. 11, 19–20 (2012).
3. Maciocia, P. M. et al. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nat. Med. 23, 1416–1423 (2017).
4. Ferrari, M. et al. Abstract 2183: targeting TRBC1 and 2 for the treatment of T cell lymphomas. Cancer Res. 80, 2183 (2020).
5. Cwynarski, K. et al. First in human study of AUTO4, a TRBC1-targeting CAR T-cell therapy in relapsed/refractory TRBC1-positive peripheral T-cell lymphoma. Blood 140, 10316–10317 (2022).
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