WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
https://www.nature.com/articles/s41392-021-00660-x.pdf
Reference5 articles.
1. Lv, Y. et al. Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRbeta-IL-6 axis in MUC1-positive cervical cancer. Oncogenesis 8, 70 (2019).
2. Kufe, D. W. MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis 41, 1173–1183 (2020).
3. Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer Statistics, 2021. CA Cancer J. Clin. 71, 7–33 (2021).
4. Zhi, X. & Chen, C. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. Cell. Mol. Life Sci. 69, 1425–1434 (2012).
5. Sha, Z., Schnell, H. M., Ruoff, K. & Goldberg, A. Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation. J. Cell Biol. 217, 1757–1776 (2018).
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