K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature22988.pdf
Reference51 articles.
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2. Devilliers, M. et al. Activation of TREK-1 by morphine results in analgesia without adverse side effects. Nat. Commun. 4, 2941 (2013)
3. Vivier, D. et al. Development of the first two-pore domain potassium channel TWIK-related K+ channel 1-selective agonist possessing in vivo anti-nociceptive activity. J. Med. Chem. 60, 1076–1088 (2017)
4. Brohawn, S. G., del Mármol, J. & MacKinnon, R. Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science 335, 436–441 (2012)
5. Miller, A. N. & Long, S. B. Crystal structure of the human two-pore domain potassium channel K2P1. Science 335, 432–436 (2012)
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