Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein-Reference-Cited by-同舟云学术

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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

Published:2017-05-24 Issue:7657 Volume:546 Page:248-253
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Zhang Yan,Sun Bingfa,Feng Dan,Hu Hongli,Chu Matthew,Qu Qianhui,Tarrasch Jeffrey T.,Li Shane,Sun Kobilka Tong,Kobilka Brian K.,Skiniotis Georgios

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature22394.pdf

Reference55 articles.

1. Drucker, D. J. The cardiovascular biology of glucagon-like peptide-1. Cell Metab. 24, 15–30 (2016)

2. Cho, Y. M., Merchant, C. E. & Kieffer, T. J. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacol. Ther. 135, 247–278 (2012)

3. Lagerström, M. C. & Schiöth, H. B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov. 7, 339–357 (2008)

4. Runge, S., Thøgersen, H., Madsen, K., Lau, J. & Rudolph, R. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J. Biol. Chem. 283, 11340–11347 (2008)

5. Underwood, C. R. et al. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J. Biol. Chem. 285, 723–730 (2010)

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