Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit-Reference-Cited by-同舟云学术

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Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit

Published:2014-11-10 Issue:12 Volume:21 Page:1028-1034
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Cevher Murat A,Shi Yi,Li Dan,Chait Brian T,Malik Sohail,Roeder Robert G

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.2914.pdf

Reference58 articles.

1. Roeder, R.G. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579, 909–915 (2005).

2. Malik, S. & Roeder, R.G. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 11, 761–772 (2010).

3. Baek, H.J., Malik, S., Qin, J. & Roeder, R.G. Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol. Cell. Biol. 22, 2842–2852 (2002).

4. Malik, S., Baek, H.J., Wu, W. & Roeder, R.G. Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator. Mol. Cell. Biol. 25, 2117–2129 (2005).

5. Mittler, G., Kremmer, E., Timmers, H.T. & Meisterernst, M. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep. 2, 808–813 (2001).

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