Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance—is insulin resistance initiated in the adipose tissue?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Link
http://www.nature.com/articles/0802028.pdf
Reference59 articles.
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3. Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF . Disruption of IRS-2 causes type 2 diabetes in mice Nature 1998 391: 900–904.
4. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB . Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance Nature Med 2000 6: 924–928.
5. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB . Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver Nature 2001 409: 729–733.
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