Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
http://www.nature.com/articles/ncb0400_205.pdf
Reference48 articles.
1. Selkoe, D. J. Translating cell biology into therapeutic advances in Alzheimer’s disease . Nature 399, A23–A31 (1999).
2. De Strooper, B. et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387 –390 (1998).
3. Wolfe, M. S. et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398, 513–517 ( 1999).
4. Wolfe, M. S. et al. Peptidomimetic probes and molecular modeling suggest that Alzheimer’s disease γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 38, 4720– 4727 (1999).
5. Leimer, U. et al. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid β-peptide production and requires a critical aspartate residue for its function in amyloidogenesis . Biochemistry 38, 13602– 13609 (1999).
Cited by 145 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Genetic defects of gamma‐secretase genes in a multiple myeloma patient with high and dysregulated BCMA surface density: A case report;British Journal of Haematology;2023-11-13
2. Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases;Current Neuropharmacology;2023-06
3. The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue;Brain Communications;2022-12-07
4. Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage;Cell Communication and Signaling;2021-11-15
5. Evolutionary History of Alzheimer Disease-Causing Protein Family Presenilins with Pathological Implications;Journal of Molecular Evolution;2020-10-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3