Characterization of the action of S 21403 (mitiglinide) on insulin secretion and biosynthesis in normal and diabeticβ-cells

Author:

Kaiser Nurit,Nesher Rafael,Oprescu Andrei,Efendic Suad,Cerasi Erol

Publisher

Wiley

Subject

Pharmacology

Reference37 articles.

1. Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes;ABDEL-HALIM;Diabetes,1998

2. The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets;ALARCON;J. Biol. Chem.,1993

3. Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation;ALARCON;Diabetes,2002

4. Effects of glipizide on the insulin production by isolated mouse pancreatic islets;ANDERSSON;Acta Endocrinol. (Copenhagen),1980

5. BREUEL , H.P. 2004 Safety, pharmacodynamics and pharmacokinetics of S 21403 following six repeated oral doses (2.5 mg t.i.d., 5 mg t.i.d., 10 mg t.i.d., 20 mg t.i.d., 30 mg t.i.d., 40 mg t.i.d.) in 70 type 2 diabetic patients. A 7 day double-blind controlled study versus placebo

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