Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase

Author:

Kast R,Schirok H,Figueroa-Pérez S,Mittendorf J,Gnoth M J,Apeler H,Lenz J,Franz J K,Knorr A,Hütter J,Lobell M,Zimmermann K,Münter K,Augstein K H,Ehmke H,Stasch J P

Publisher

Wiley

Subject

Pharmacology

Reference28 articles.

1. Regulation and functions of Rho-associated kinase;Amano;Exp Cell Res,2000

2. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, fasudil, and H-1152P: structural basis for selectivity;Breitenlechner;Structure,2003

3. Calcium sensitization as a pharmacological target in vascular smooth muscle regulation;Christ;Curr Opin Investig Drugs,2005

4. Specificity and mechanism of action of some commonly used protein kinase inhibitors;Davies;Biochem J,2000

5. Novel Rho-kinase inhibitors with anti-inflammatory and vasodilatory activities;Doe;J Pharmacol Exp Ther,2007

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