5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide
Author:
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1038/sj.bjp.0705632/fullpdf
Reference52 articles.
1. Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline;BOUCHER;Biochem. Biophys. Res. Commun.,1992
2. Serotonin-induced vasodilatation in the human forearm is mediated by the ‘nitric oxide-pathway’: no evidence for involvement of the 5-HT3-receptor;BRUNING;J. Cardiovasc. Pharmacol.,1993
3. Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid;CAPDEVILA;Proc. Natl. Acad. Sci. U.S.A.,1981
4. Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase;CELLEK;Br. J. Pharmacol.,1996
5. Functional changes in cerebral 5-hydroxytryptamine metabolism in the mouse induced by anticonvulsant drugs;CHADWICK;Br. J. Pharmacol.,1978
Cited by 27 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study;BMC Cardiovascular Disorders;2023-04-06
2. High-altitude Hypoxia Influences the Activities of the Drug-Metabolizing Enzyme CYP3A1 and the Pharmacokinetics of Four Cardiovascular System Drugs;Pharmaceuticals;2022-10-21
3. CYP450 2D6 and 2C19 genotypes in ADHD: not related with treatment resistance but with over-representation of 2C19 ultra-metabolizers;Drug Metabolism and Personalized Therapy;2022-02-24
4. Effect of copper nanoparticles on brain cytochrome�P450 enzymes in rats;Molecular Medicine Reports;2019-05-27
5. The engagement of brain cytochrome P450 in the metabolism of endogenous neuroactive substrates: a possible role in mental disorders;Drug Metabolism Reviews;2018-10-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3