A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2in vitroandin vivoin a substrate-sensitive manner
Author:
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1038/sj.bjp.0702708/fullpdf
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4. Potencies of leflunomide and HR325 as inhibitors of prostaglandin endoperoxide H synthase-1 and -2: comparison with nonsteroidal anti-inflammatory drugs;CURNOCK;J. Pharmacol. Exp. Ther.,1997
5. Kinetic basis for selective inhibition of cyclooxygenases;GIERSE;Biochem. J.,1999
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