Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize α2 -adrenoceptors in the prefrontal cortex

Author:

Invernizzi R W,Parini S,Sacchetti G,Fracasso C,Caccia S,Annoni K,Samanin R

Publisher

Wiley

Subject

Pharmacology

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4. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals;CARBONI;J. Neurochem.,1990

5. Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat;DENNIS;J. Pharmacol. Exp. Ther.,1987

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