Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX
Author:
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1038/sj.bjp.0702901/fullpdf
Reference41 articles.
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3. Loss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis;CANNON;J. Physiol.,1993
4. Common modes of drug action on Na+ channels: local anesthetics, antiarrhythmics and anticonvulsants;CATTERALL;Trends Pharmacol. Sci.,1987
5. Fitting and Statistical Analysis of Single-Channel Records
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