Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a ‘low-affinity’ phosphodiesterase 4 conformer

Author:

Souness John E.,Houghton Clare,Sardar Nughat,Withnall Michael T.

Publisher

Wiley

Subject

Pharmacology

Reference42 articles.

1. Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R gene expression at multiple levels;ANASTASSIOU;J. Immunol.,1992

2. Selective type IV phosphodiesterase inhibitors as anti-asthmatic agents. The synthesis and biological activities of 3-cyclopentyloxy-4-methoxybenzamides and analogues;ASHTON;J. Med. Chem.,1994

3. Control of human T-lymphocyte interleukin-2 production by a cyclic AMP-dependent pathway;AVERILL;Cell. Immunol.,1988

4. Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: Correlation between function and interaction with a high-affinity rolipram binding site;BARNETTE;J. Pharmacol. Exp. Ther.,1995a

5. Association of the antiinflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H] rolipram binding;BARNETTE;Biochem. Pharmacol.,1996

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