Genome instability: a mechanistic view of its causes and consequences
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg2268.pdf
Reference153 articles.
1. Maizels, N. Immunoglobulin gene diversification. Annu. Rev. Genet. 39, 23–46 (2005).
2. McMurray, M. A. & Gottschling, D. E. An age-induced switch to a hyper-recombinational state. Science 301, 1908–1911 (2003). This paper describes a strong increase in genomic instability that is linked to ageing in the budding yeast, S. cerevisiae . This constitutes a rational explanation for the association of high cancer risk with age in mammals.
3. Draviam, V. M., Xie, S. & Sorger, P. K. Chromosome segregation and genomic stability. Curr. Opin. Genet. Dev. 14, 120–125 (2004).
4. Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907–913 (2005). This paper shows that the DNA-damage response is activated in a panel of human lung hyperplasias, whereas its inactivation leads to malignant transformation, pointing to a role of checkpoints as a natural anticancer barrier.
5. Friedberg, E. C. et al. DNA Repair and Mutagenesis 461–750 (American Society For Microbiology Press, Washington DC, 2006).
Cited by 627 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Current status and prospect of the DNA double-strand break repair pathway in colorectal cancer development and treatment;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-10
2. Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.;DNA Repair;2024-09
3. Broken strands, broken minds: Exploring the nexus of DNA damage and neurodegeneration;DNA Repair;2024-08
4. Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches;Molecular Cancer;2024-07-25
5. RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity;Genes & Development;2024-07-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3