Abstract
AbstractMetal allergy is one of the typical immune disorders encountered during the application of dental/medical materials and has a highly complex pathogenic mechanism. Semaphorin 3A (Sema3A), a member of the semaphorin family, is reported to be involved in various immune disorders. However, its role in metal allergy has not been clarified yet. Herein, we show that Sema3A expression was upregulated in nickel (Ni) allergy-induced mouse ear tissue and in NiCl2-stimulated mouse keratinocytes. Moreover, Sema3A regulated tumor necrosis factor-alpha production and mitogen-activated protein kinase activation in keratinocytes. The specific deletion of Sema3A in keratinocytes did not affect immune cell infiltration but reduced edema and ear swelling; it also impeded Th1 responses to cause a slight alleviation in Ni allergy in mice. Our results demonstrate that Sema3A promotes the development of metal allergy and should be explored as a potential target for the prevention and treatment of metal allergy.
Funder
MEXT | Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference59 articles.
1. Lundström, I. M. Allergy and corrosion of dental materials in patients with oral lichen planus. Int. J. Oral. Surg. 13, 16–24 (1984).
2. Scalf, L. A., Fowler, J. F. Jr, Morgan, K. W. & Looney, S. W. Dental metal allergy in patients with oral, cutaneous, and genital lichenoid reactions. Am. J. Contact Dermat. 12, 146–150 (2001).
3. Mizoguchi, S., Setoyama, M. & Kanzaki, T. Linear lichen planus in the region of the mandibular nerve caused by an allergy to palladium in dental metals. Dermatology 196, 268–270 (1998).
4. Laine, J., Kalimo, K. & Happonen, R. P. Contact allergy to dental restorative materials in patients with oral lichenoid lesions. Contact Dermat. 36, 141–146 (1997).
5. Song, H., Yin, W. & Ma, Q. Allergic palmoplantar pustulosis caused by cobalt in cast dental crowns: a case report. Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod. 111, e8–e10 (2011).
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献