Abstract
AbstractWhile SARS-CoV-2 is causing modern human history’s most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different scenarios potentially explaining how the viral RNA can bypass its own translation blockage and speculate on the suitability of Nsp1 as a therapeutic target.
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung - NCCR RNA & Disease
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference33 articles.
1. Zhu, N. China Novel Coronavirus Investigating and Research Team et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727–733 (2020).
2. WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19—11-march-2020 (2020).
3. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int (2020).
4. Phylogeny of SARS-like betacoronaviruses including novel coronavirus SARS-CoV-2. https://nextstrain.org/groups/blab/sars-like-cov (2020).
5. Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273 (2020).
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献