Regulating epithelial-mesenchymal plasticity from 3D genome organization-Reference-Cited by-同舟云学术

Regulating epithelial-mesenchymal plasticity from 3D genome organization

Published:2024-06-20 Issue:1 Volume:7 Page:
ISSN:2399-3642
Container-title:Communications Biology
language:en
Short-container-title:Commun Biol

Author:

Pang Qing You^ORCID,Chiu Yi-Chia,Huang Ruby Yun-Ju^ORCID

Abstract

AbstractEpithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression. As our understanding evolves, it is clear the reversible execution of EMT arises from complex epigenomic regulation involving histone modifications and 3-dimensional (3D) genome structural changes, leading to a cascade of transcriptional events. This review summarizes current knowledge on chromatin organization in EMT, with a focus on hierarchical structures of the 3D genome and chromatin accessibility changes.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s42003-024-06441-w.pdf

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