Human subsistence and signatures of selection on chemosensory genes

Author:

Veilleux Carrie C.ORCID,Garrett Eva C.,Pajic Petar,Saitou MarieORCID,Ochieng Joseph,Dagsaan Lilia D.,Dominy Nathaniel J.ORCID,Perry George H.,Gokcumen OmerORCID,Melin Amanda D.ORCID

Abstract

AbstractChemosensation (olfaction, taste) is essential for detecting and assessing foods, such that dietary shifts elicit evolutionary changes in vertebrate chemosensory genes. The transition from hunting and gathering to agriculture dramatically altered how humans acquire food. Recent genetic and linguistic studies suggest agriculture may have precipitated olfactory degeneration. Here, we explore the effects of subsistence behaviors on olfactory (OR) and taste (TASR) receptor genes among rainforest foragers and neighboring agriculturalists in Africa and Southeast Asia. We analyze 378 functional OR and 26 functional TASR genes in 133 individuals across populations in Uganda (Twa, Sua, BaKiga) and the Philippines (Agta, Mamanwa, Manobo) with differing subsistence histories. We find no evidence of relaxed selection on chemosensory genes in agricultural populations. However, we identify subsistence-related signatures of local adaptation on chemosensory genes within each geographic region. Our results highlight the importance of culture, subsistence economy, and drift in human chemosensory perception.

Funder

American Association of University Women

Wenner-Gren Foundation

David and Lucile Packard Foundation

U.S. Department of Health & Human Services | National Institutes of Health

National Science Foundation

Canada Research Chairs

National Science and Engineering Research Council of Canada

Publisher

Springer Science and Business Media LLC

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

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