Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases-Reference-Cited by-同舟云学术

Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases

Published:2024-03-29 Issue:1 Volume:7 Page:
ISSN:2399-3642
Container-title:Communications Biology
language:en
Short-container-title:Commun Biol

Author:

Liu Jingwei,Xiao Yutong,Cao Liangzi,Lu Songming,Zhang Siyi,Yang Ruohan,Wang Yubang,Zhang Naijin,Yu Yang,Wang Xiwen,Guo Wendong,Wang Zhuo,Xu Hongde^ORCID,Xing Chengzhong,Song Xiaoyu^ORCID,Cao Liu^ORCID

Abstract

AbstractAutophagy is a dynamic self-renovation biological process that maintains cell homeostasis and is responsible for the quality control of proteins, organelles, and energy metabolism. The E1-like ubiquitin-activating enzyme autophagy-related gene 7 (ATG7) is a critical factor that initiates classic autophagy reactions by promoting the formation and extension of autophagosome membranes. Recent studies have identified the key functions of ATG7 in regulating the cell cycle, apoptosis, and metabolism associated with the occurrence and development of multiple diseases. This review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and the relationship between ATG7 and aging-related diseases.

Funder

the key project of the National Natural Science Foundation

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s42003-024-06080-1.pdf

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