Abstract
AbstractIn-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference90 articles.
1. Marfurt, C. F., Cox, J., Deek, S. & Dvorscak, L. Anatomy of the human corneal innervation. Exp. Eye Res. 90, 478–492 (2010).
2. Minsky, M. Memoir on inventing the confocal scanning microscope. Scanning 10, 128–138 (1988).
3. Sheppard, C. J. R., Hamilton, D. K., Cox, I. J. & Cullen, A. L. Optical microscopy with extended depth of field. Proc. R. Soc. Lond. A 387, 171–186 (1997).
4. Chirapapaisan, C., Thongsuwan, S., Chirapapaisan, N., Chonpimai, P. & Veeraburinon, A. Characteristics of corneal subbasal nerves in different age groups: an in vivo confocal microscopic analysis. Clin. Ophthalmol. 15, 3563–3572 (2021).
5. Misra, S. L., Goh, Y. W., Patel, D. V., Riley, A. F. & McGhee, C. N. J. Corneal microstructural changes in nerve fiber, endothelial and epithelial density after cataract surgery in patients with diabetes mellitus. Cornea 34, 177–181 (2015).
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献