MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex-Reference-Cited by-同舟云学术

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MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex

Published:2019-01-18 Issue:1 Volume:2 Page:
ISSN:2399-3642
Container-title:Communications Biology
language:en
Short-container-title:Commun Biol

Author:

Abe Yoshinori^ORCID,Suzuki Yosuke,Kawamura Kenji,Tanaka Nobuyuki

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

http://www.nature.com/articles/s42003-018-0275-4.pdf

Reference55 articles.

1. Kinzler, K. W. et al. Identification of an amplified, highly expressed gene in a human glioma. Science 236, 70–73 (1987).

2. Ng, J. M. & Curran, T. The Hedgehog’s tale: developing strategies for targeting cancer. Nat. Rev. Cancer 11, 493–501 (2011).

3. Hui, C. C. & Angers, S. Gli proteins in development and disease. Annu. Rev. Cell Dev. Biol. 27, 513–537 (2011).

4. Ingham, P. W. & McMahon, A. P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059–3087 (2001).

5. Beachy, P. A., Karhadkar, S. S. & Berman, D. M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432, 324–331 (2004).

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